Read about our work

S. Zhou, H. Bhukya, N. Malet, P.J. Harrison, D. Rea, M.J. Belousoff, H. Venugopal, P.K. Sydor, K.M. Styles, L. Song, M.J. Cryle, L.M. Alkhalaf, V. Fülöp, G.L. Challis and C. Corre. Structural basis for control of antibiotic production by a bacterial hormone. BioRxiv, 2020, doi:10.1101/2020.05.02.073981.

A. Chhun, D. Sousoni, M. Aguiló-Ferretjans, L. Song, C. Corre and J.A. Christie-Oleza. Phytoplankton trigger the production of cryptic metabolites in the marine actinobacteria Salinispora tropica. BioRxiv, 2020, doi:10.1101/2020.05.18.103358.

D. Kaur, C. Corre and F. Alberti. Engineering isoprenoid quinone production in yeast. BioRxiv, 2020, doi:10.1101/2020.02.06.932020.

J. Furner-Pardoe, B. O. Anonye, R. Cain, J. Moat, C.A. Ortori, C. Lee, D.A. Barrett, C. Corre and F. Harrison. Anti-biofilm efficacy of a medieval treatment for bacterial infection requires the combination of multiple ingredients. Sci. Rep., 2020, 10: 12687. 


F. Alberti, C. Corre. Editing streptomycete genomes in the CRISPR/Cas9 age. Nat Prod Rep, 2019, doi:  10.1039/c8np00081f.

F. Alberti, D. Leng, I. Wilkening, L. Song, M. Tosin and C. Corre. Triggering the expression of a silent gene cluster from genetically intractable bacteria results in scleric acid discovery. Chem Sci, 2019, doi: 10.1039/C8SC03814G.


J. Bowyer, E.L.C. de los Santos, K.M. Styles, A. Fullwood, C. Corre and D.G. Bates. Modeling the Architecture of the Regulatory System Controlling Methylenomycin Production in Streptomyces coelicolor. Journal of Biological Engineering, 2017, 11: 30. 

doi: 10.1186/s13036-017-0071-6, 2017.

X. Li, J. Wang, M. Shi, W. Wang, C. Corre and K. Yang. Evidence for the formation of ScbR/ScbR2 heterodimers and identification of one of the regulatory targets in Streptomyces coelicolor. Appl. Microbiol. Biotechnol., 2017, 101: 5333-5340.

doi: 10.1007/s00253-017-8275-8.


J.D. Sidda, V. Poon, L. Song, W. Wang, K. Yang and C. Corre. Overproduction and identification of butyrolactones SCB1-8 in the antibiotic production superhost Streptomyces M1152. Org. Biomol. Chem., 2016, 14: 6390-6393.

W. Wang, T. Yang, Y. Li, S. Li, S. Yin, K. Styles, C. Corre and K. Yang. Development of a synthetic oxytetracycline-inducible expression system for streptomycetes using de novo characterized genetic partsACS Synth. Biol., 2016, 5: 765-773.


J. D. Sidda, L. Song, V. Poon, M. Al-Bassam, O. Lazos, M. J. Buttner, G. L. Challis and C. Corre. Discovery of a family of g-aminobutyrate ureas via rational derepression of a silent bacterial gene cluster. Chem. Sci., 2014, 5: 86-89.

doi: 10.1039/C3SC52536H


L. Song, L. Laureti, C. Corre, P. Leblond, B. Aigle and G.L. Challis. Cytochrome P450-mediated hydroxylation is required for polyketide macrolactonisation in stambomycin biosynthesis. J. Antibiot., 2014, 67: 71-76.


C. Corre. In search of the missing ligands for TetR family regulators. Chem. Biol. 2013, 20: 140-142.


J. D. Sidda and C. Corre. Gamma-butyrolactone and furan signalling systems in Streptomyces. Methods in Enzymol., 2012, 517: 71-87.


L. Song, L. Laureti, J.-P. Gomez-Escribano, D. Fox, V. Yeo, C. Corre, S. Huang, P. Leblond, B. Aigle, M. Bibb and G. L. Challis. Bacterial Genome Mining for Novel Natural Product Discovery. Planta Med., 2012, 78: 1030.


B. Aigle and C. Corre. Waking up Streptomyces secondary metabolism by constitutive expression of activators or genetic disruption of repressors. Methods in Enzymol. 2012, 517: 343-366.


P.K. Sydor, S. M. Barry, O.M. Odulate, F. Barona-Gomez, S.W. Haynes, C. Corre, L. Song, and G.L. Challis. Regio- and stereodivergent antibiotic oxidative carbocyclizations catalyzed by Rieske oxygenase-like enzymes. Nat. Chem., 2011, 3: 388-392.

B. Aigle, R. Bunet, C. Corre, A. Garenaux, L. Hotel, S. Huang, L. Laureti, S. Lautru, M. V. Mendes, S. Nezbedova, H. C. Nguyen, L. Song, J. Weiser, G. Challis, P. Leblond, J.-L. Pernodet. Genome-guided exploration of Streptomyces ambofaciens secondary metabolism.  Streptomyces, 2011, 179-194.

S.W. Haynes, P.K. Sydor, C. Corre, L. Song, and G.L. Challis. Stereochemical elucidation of streptorubin. B. J. Am. Chem. Soc., 2011, 133: 1793-98.

L. Laureti, L. Song, S. Huang, C. Corre, P. Leblond, G.L. Challis and B. Aigle. Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens. Proc. Natl. Acad. Sci. USA, 2011, 108: 6258-6263.

R. Bunet, L. Song, M.V. Mendes, C. Corre, L. Hotel, N. Rouhier, X. Framboisier, P. Leblond, G.L. Challis and B. Aigle. Characterization and manipulation of the pathway-specific late regulator AlpW reveals Streptomyces ambofaciens as a new producer of kinamycins. J. Bact. 2011, 193: 1142-1153.

S.W. Haynes, P.K. Sydor, C. Corre and G.L. Challis. Elucidation of pathways for antibiotic biosynthesis in Streptomyces coelicolor A3(2). In Functional molecules from natural sources. Wrigley S.K., Thomas, R., Nicholson, N., Bedford, C., Eds.; Royal Society of Chemistry: Cambridge, 2011; pp 149-160.



C. Corre, S.W. Haynes, N. Malet, L. Song, and G.L. Challis. A butenolide intermediate in methylenomycin furan biosynthesis is implied by incorporation of stereospecifically 13C-labelled glycerols. Chem. Commun., 2010, 46: 4079-4081.

C. Corre and G.L. Challis. Exploiting genomics for new natural product discovery in prokaryotes. In Comprehensive Natural Products Chemistry II Chemistry and Biology; Mander, L., Liu, H.-W., Eds.; Elsevier: Oxford, 2010; volume 2, pp.429-453.



C. Corre and G.L. Challis. New natural product biosynthetic chemistry from genome mining. Nat. Prod. Rep., 2009, 26: 977-986.

S. O’Rourke, A. Wietzorrek, K. Fowler, C. Corre, G.L. Challis and K.F. Chater. Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor. Mol. Microbiol., 2009, 71: 763-778.



C. Corre, L. Song, S. O’Rourke, K.F. Chater and G.L. Challis. 2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids, a new class of antibiotic biosynthesis inducers discovered by Streptomyces coelicolor genome mining. Proc. Natl Acad. Sci. USA, 2008, 105: 17510-17515. 

doi: 10.1073/pnas.0805530105

S. Mo, P.K. Sydor, C. Corre, M.M. Alhamadsheh, A.E. Stanley, S.W. Haynes, L. Song, K.A. Reynolds and G.L. Challis. Elucidation of the Streptomyces coelicolor pathway to 2-undecylpyrrole, a key intermediate in undecylprodiginine and streptorubin B biosynthesis. Chem. Biol., 2008, 15: 137-148.

K. Chen, N.S. Rannulu, Y. Cai, P. Lane, A.L. Liebl, B.B. Rees, C. Corre, G.L. Challis and R.B. Cole. Unusual odd-electron fragments from even-electron protonated prodiginine precursors using positive-ion electrospray tandem mass spectrometry. J. Am. Soc. Mass Spectrom., 2008, 19: 1856-1866.




C. Corre and G.L. Challis. Heavy tools for genome mining. Chem. Biol., 2007, 14: 7-9.




L. Song, F. Barona-Gomez, C. Corre, L. Xiang, D.W. Udwary, M.B. Austin, J.P. Noel, B.S. Moore and G.L. Challis. Type III polyketide synthase b-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining. J. Am. Chem. Soc., 2006, 128: 14754.


L.J. Walton, C. Corre, and G.L. Challis. Mechanisms for the incorporation of glycerol-derived precursors into polyketide metabolites. J. Industrial Microbiol. Biotechnol., 2006, 33: 105-120.


A.E. Stanley, M. Kourdi-Zerikly, L.J. Walton, C. Corre and G.L. Challis. Elucidation of the Streptomyces coelicolor pathway to 4-methoxy-2,2’-bipyrrole-5-carboxaldehyde, an intermediate in prodiginine biosynthesis. Chem. Commun., 2006, 3981-3983.



C. Corre and G.L. Challis.  Evidence for the unusual condensation of a diketide with a pentose sugar in the methylenomycin biosynthetic pathway of Streptomyces coelicolor A3(2). ChemBioChem., 2005, 6: 2166-2170.


C. Corre, C.A.S. Landreau, M. Shipman, and P.A.S. Lowden. Biosynthetic studies on the azinomycins: The pathway to the naphthoate fragment. Chem. Commun., 2004, 2600-2601.

C. Corre and P.A.S. Lowden. The first biosynthetic studies of the azinomycins: Acetate incorporation into azinomycin B. Chem. Commun., 2004, 990-99.


B. Méhul, C. Corre, C. Capon, D. Bernard, and R. Schmidt. Carbohydrate expression and modification during keratinocyte differentiation in normal human and reconstructed epidermis. Exp. Dermatology, 2003, 12: 537-545.

School of Life Sciences, The University of Warwick

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